cPLA2 a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Arachidonic acid is a precursor for the eicosanoids that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Promotes cerebellar long-term depression and motor learning. Translocates to the Golgi and endoplasmic reticulum in a calcium-dependent fashion. Translocation and activation of at the ER facilitates the process of ER stress. Regulates the biogenesis of lipid droplets, a process dependent on JNK and ceramide kinase. Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Inhibited when in trimolecular complex with ANXA2 and S100A10. Phosphorylation of S727 relieves this inhibitory interaction, thus activating PLA2G4A. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase
Chromosomal Location of Human Ortholog: 13q21
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; intracellular membrane-bounded organelle; lipid droplet; nucleus; perinuclear region of cytoplasm; zymogen granule
Molecular Function:  calcium ion binding; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; histone acetyltransferase binding; lysophospholipase activity; phospholipase A2 activity; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine); phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
Biological Process:  aging; arachidonic acid metabolic process; arachidonic acid secretion; cellular response to antibiotic; decidualization; glycerophospholipid catabolic process; icosanoid biosynthetic process; luteolysis; ovulation from ovarian follicle; phospholipid catabolic process; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of cell proliferation; positive regulation of fever generation; positive regulation of inflammatory response; positive regulation of prostaglandin biosynthetic process; positive regulation of vesicle fusion; regulation of cell proliferation; response to calcium ion; response to glucocorticoid; response to heat; response to hormone; response to hydrogen peroxide; response to lipopolysaccharide; response to lithium ion; response to methylmercury; response to organic substance; response to organonitrogen compound; response to vitamin D; surfactant homeostasis
Reference #:  P50393 (UniProtKB)
Alt. Names/Synonyms: Cpla2; Cytosolic phospholipase A2; Lysophospholipase; PA24A; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; phospholipase A2 cytosolic; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent); Pla2c; Pla2g4; Pla2g4a
Gene Symbols: Pla2g4a
Molecular weight: 85,707 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene