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Siglec-10
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1. In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. In association with CD24 may regulate the immune repsonse of natural killer (NK) cells. Plays a role in the control of autoimmunity. During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 19q13.41 |
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Cellular Component:
extracellular region; plasma membrane
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Molecular Function:
carbohydrate binding; phosphatase binding; protein binding; SH2 domain binding; sialic acid binding
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Biological Process:
adaptive immune response; cell adhesion; innate immune response; negative regulation of inflammatory response to wounding
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Reference #:
Q96LC7
(UniProtKB)
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Alt. Names/Synonyms: MGC126774; PRO940; sialic acid binding Ig like lectin 10; sialic acid binding Ig-like lectin 10; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; Sialic acid-binding Ig-like lectin 10; SIG10; Siglec-10; siglec-like gene 2; Siglec-like protein 2; SIGLEC10; SLG2
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Gene Symbols: SIGLEC10
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Molecular weight:
76,592 Da
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Basal Isoelectric point:
8.69
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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