TERT Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. Belongs to the reverse transcriptase family. Telomerase subfamily. Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T-lymphocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Nucleolus; Transferase
Chromosomal Location of Human Ortholog: 13 C1|13 40.12 cM
Cellular Component:  chromosome; chromosome, telomeric region; cytoplasm; cytosol; mitochondrial nucleoid; mitochondrion; nuclear chromosome, telomeric region; nuclear speck; nucleolus; nucleoplasm; nucleus; plasma membrane; RNA-directed RNA polymerase complex; telomerase catalytic core complex; telomerase holoenzyme complex; TERT-RMRP complex
Molecular Function:  chaperone binding; DNA binding; identical protein binding; metal ion binding; nucleotidyltransferase activity; protein binding; protein C-terminus binding; protein homodimerization activity; protein N-terminus binding; RNA binding; RNA-directed 5'-3' RNA polymerase activity; RNA-directed DNA polymerase activity; telomerase activity; telomerase RNA binding; telomerase RNA reverse transcriptase activity; telomeric DNA binding; template-free RNA nucleotidyltransferase; transcription coactivator binding; transferase activity; tRNA binding
Biological Process:  cellular response to hypoxia; DNA biosynthetic process; DNA strand elongation; establishment of protein localization to telomere; mitochondrion organization; negative regulation of apoptotic process; negative regulation of cellular senescence; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of gene expression; negative regulation of glial cell proliferation; negative regulation of neuron apoptotic process; negative regulation of production of siRNA involved in RNA interference; positive regulation of angiogenesis; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of glucose import; positive regulation of hair cycle; positive regulation of nitric-oxide synthase activity; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of protein binding; positive regulation of protein localization to nucleolus; positive regulation of stem cell proliferation; positive regulation of transdifferentiation; positive regulation of vascular associated smooth muscle cell migration; positive regulation of vascular smooth muscle cell proliferation; positive regulation of Wnt signaling pathway; production of siRNA involved in RNA interference; regulation of histone demethylase activity (H3-K4 specific); regulation of protein stability; replicative senescence; RNA-dependent DNA biosynthetic process; telomere maintenance via telomerase; transcription, RNA-templated
Reference #:  O70372 (UniProtKB)
Alt. Names/Synonyms: EST2; MGC150124; TCS1; Telomerase catalytic subunit; Telomerase reverse transcriptase; telomerase reverse transcriptase beta; Tert; TP2; TRT
Gene Symbols: Tert
Molecular weight: 127,978 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene