NRF2 Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. Belongs to the bZIP family. CNC subfamily. Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 2q31.2
Cellular Component:  centrosome; chromatin; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus; plasma membrane; protein-DNA complex; RNA polymerase II transcription regulator complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein domain specific binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding; transcription coregulator binding; ubiquitin protein ligase binding
Biological Process:  aflatoxin catabolic process; cell redox homeostasis; cellular response to angiotensin; cellular response to copper ion; cellular response to fluid shear stress; cellular response to glucose starvation; cellular response to hydrogen peroxide; cellular response to laminar fluid shear stress; cellular response to oxidative stress; cellular response to tumor necrosis factor; cellular response to xenobiotic stimulus; endoplasmic reticulum unfolded protein response; inflammatory response; integrated stress response signaling; negative regulation of cardiac muscle cell apoptotic process; negative regulation of cellular response to hypoxia; negative regulation of endothelial cell apoptotic process; negative regulation of hematopoietic stem cell differentiation; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of vascular associated smooth muscle cell migration; PERK-mediated unfolded protein response; positive regulation of angiogenesis; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glutathione biosynthetic process; positive regulation of neuron projection development; positive regulation of reactive oxygen species metabolic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of transcription from RNA polymerase II promoter in response to stress; proteasomal ubiquitin-independent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of cellular response to oxidative stress; regulation of embryonic development; regulation of innate immune response; regulation of removal of superoxide radicals; regulation of transcription by RNA polymerase II; response to ischemia; response to oxidative stress
Disease: Immunodeficiency, Developmental Delay, And Hypohomocysteinemia
Reference #:  Q16236 (UniProtKB)
Alt. Names/Synonyms: HEBP1; IMDDHH; NF-E2-related factor 2; NF2L2; NFE2-related factor 2; NFE2L2; Nrf-2; NRF2; nuclear factor (erythroid-derived 2)-like 2; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2 like 2; Nuclear factor, erythroid derived 2, like 2
Gene Symbols: NFE2L2
Molecular weight: 67,826 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NRF2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein