perilipin 1 Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. Detected in adipocytes from white adipose tissue (at protein level) (PubMed:27832861). Detected in visceral adipose tissue and mammary gland (PubMed:9521880). Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of rat Ortholog: 1q31
Cellular Component:  cytosol; endoplasmic reticulum; lipid droplet
Biological Process:  lipid catabolic process; lipid metabolic process
Reference #:  P43884 (UniProtKB)
Alt. Names/Synonyms: Lipid droplet-associated protein; Peri; PERIA; perilipin; perilipin 1; Perilipin-1; Plin; Plin1
Gene Symbols: Plin1
Molecular weight: 55,614 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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perilipin 1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene