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perilipin 1
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. Belongs to the perilipin family. Detected in adipocytes from white adipose tissue (at protein level) (PubMed:27832861). Detected in visceral adipose tissue and mammary gland (PubMed:9521880). Note: This description may include information from UniProtKB.
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| Protein type: Lipid-binding |
| Chromosomal Location of human Ortholog: 15q26.1 |
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Cellular Component:
cytosol; endoplasmic reticulum; lipid droplet
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Molecular Function:
lipid binding; protein binding
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Biological Process:
cellular response to cold; lipid catabolic process; lipid metabolic process
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Disease: Lipodystrophy, Familial Partial, Type 4
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Reference #:
O60240
(UniProtKB)
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Alt. Names/Synonyms: FPLD4; Lipid droplet-associated protein; PERI; perilipin 1; Perilipin-1; PLIN; PLIN1
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Gene Symbols: PLIN1
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Molecular weight:
55,990 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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