PKCI Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. Note: This description may include information from UniProtKB.
Protein type: AGC group; Cell adhesion; Cell development/differentiation; EC; Iota subfamily; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 2q24
Cellular Component:  apical part of cell; apical plasma membrane; cell leading edge; cytoplasm; cytosol; endosome; glutamatergic synapse; Golgi membrane; intercellular bridge; microtubule cytoskeleton; nucleus; plasma membrane; Schaffer collateral - CA1 synapse; Schmidt-Lanterman incisure
Molecular Function:  ATP binding; metal ion binding; phospholipid binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity
Biological Process:  actin filament organization; cell migration; cell-cell junction organization; cellular protein localization; cellular response to insulin stimulus; establishment of apical/basal cell polarity; eye photoreceptor cell development; Golgi vesicle budding; intracellular signal transduction; negative regulation of glial cell apoptotic process; negative regulation of neuron apoptotic process; peptidyl-serine phosphorylation; positive regulation of endothelial cell apoptotic process; positive regulation of glial cell proliferation; positive regulation of glucose import; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein localization to plasma membrane; protein phosphorylation; regulation of postsynaptic membrane neurotransmitter receptor levels; response to interleukin-1; response to peptide hormone
Reference #:  F1M7Y5 (UniProtKB)
Alt. Names/Synonyms: Pkci; PKCI-1; Pkci1; Prkci; Protein kinase C iota type; protein kinase C, iota
Gene Symbols: Prkci
Molecular weight: 68,276 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene