GLT1 Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2 E2|2 54.13 cM
Cellular Component:  axolemma; axon; cell surface; dendritic shaft; dendritic spine; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of presynaptic membrane; membrane; neuron projection; plasma membrane; presynaptic membrane; synapse
Molecular Function:  anion transmembrane transporter activity; glutamate:sodium symporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; metal ion binding; symporter activity
Biological Process:  adult behavior; amino acid transport; anion transmembrane transport; cellular response to extracellular stimulus; D-aspartate import across plasma membrane; L-glutamate import across plasma membrane; L-glutamate transmembrane transport; multicellular organism aging; multicellular organism growth; nervous system development; neurotransmitter reuptake; positive regulation of glucose import; protein homotrimerization; response to amino acid; response to drug; response to light stimulus; response to wounding; telencephalon development; visual behavior
Reference #:  P43006 (UniProtKB)
Alt. Names/Synonyms: 1700091C19Rik; 2900019G14Rik; AI159670; EAA2; Eaat2; Excitatory amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; Glt1; MGLT1; OTTMUSP00000015765; OTTMUSP00000015766; OTTMUSP00000015767; Slc1a2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
Gene Symbols: Slc1a2
Molecular weight: 62,030 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene