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GLT1
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of mouse Ortholog: 2 E2|2 54.13 cM |
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Cellular Component:
astrocyte projection; axolemma; axon; cell body; cell surface; dendritic shaft; dendritic spine; glutamatergic synapse; membrane; membrane protein complex; membrane raft; neuron projection terminus; plasma membrane; presynaptic membrane; synapse; vesicle
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Molecular Function:
cysteine transmembrane transporter activity; glutamate:sodium symporter activity; high-affinity L-glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; metal ion binding; monoatomic anion transmembrane transporter activity; neutral L-amino acid transmembrane transporter activity; symporter activity
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Biological Process:
adult behavior; amino acid transport; cellular response to cocaine; cellular response to extracellular stimulus; D-aspartate import across plasma membrane; glutathione biosynthetic process; L-aspartate import across plasma membrane; L-aspartate transmembrane transport; L-glutamate import across plasma membrane; L-glutamate transmembrane transport; monoatomic anion transmembrane transport; multicellular organism growth; nervous system development; neurotransmitter reuptake; positive regulation of glucose import; protein homotrimerization; response to amino acid; response to light stimulus; response to wounding; response to xenobiotic stimulus; telencephalon development; visual behavior
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Reference #:
P43006
(UniProtKB)
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Alt. Names/Synonyms: 1700091C19Rik; 2900019G14Rik; AI159670; Eaa; EAA2; Eaat2; EAAT2 variant mEAAT2/5UT2; EAAT2 variant mEAAT2/5UT5; Excitatory amino acid transporter 2; glial high affinity glutamate transporter; GLT; GLT-; GLT-1; Glt1; glutamate transporter 1c; MGLT; MGLT1; OTTMUSP00000015765; OTTMUSP00000015766; OTTMUSP00000015767; Slc1a2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
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Gene Symbols: Slc1a2
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Molecular weight:
62,030 Da
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Basal Isoelectric point:
6.24
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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