GLT1 Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 11p13
Cellular Component:  astrocyte projection; axolemma; cell body; cell surface; glutamatergic synapse; membrane; membrane protein complex; membrane raft; neuron projection terminus; plasma membrane; presynaptic membrane; vesicle
Molecular Function:  cysteine transmembrane transporter activity; glutamate:sodium symporter activity; high-affinity L-glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; metal ion binding; monoatomic anion transmembrane transporter activity; neutral L-amino acid transmembrane transporter activity; protein binding
Biological Process:  adult behavior; cellular response to cocaine; cellular response to extracellular stimulus; chemical synaptic transmission; cysteine transmembrane transport; D-aspartate import across plasma membrane; glutathione biosynthetic process; L-aspartate import across plasma membrane; L-aspartate transmembrane transport; L-glutamate import across plasma membrane; L-glutamate transmembrane transport; monoatomic anion transmembrane transport; monoatomic ion transport; multicellular organism growth; neurotransmitter reuptake; neurotransmitter transport; positive regulation of glucose import; protein homotrimerization; response to amino acid; response to wounding; response to xenobiotic stimulus; telencephalon development; transepithelial transport; transport across blood-brain barrier; visual behavior
Disease: Epileptic Encephalopathy, Early Infantile, 41
Reference #:  P43004 (UniProtKB)
Alt. Names/Synonyms: EAA2; EAAT2; EIEE41; Excitatory amino acid transporter 2; excitotoxic amino acid transporter 2; glial high affinity glutamate transporter; GLT-1; GLT1; Glutamate/aspartate transporter II; HBGT; SLC1A2; Sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2; solute carrier family 1, member 2
Gene Symbols: SLC1A2
Molecular weight: 62,104 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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