DTX3L E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. By monoubiquitinating histone H2B HIST1H2BH/H2BJ and thereby promoting chromatin remodeling, positively regulates STAT1-dependent interferon-stimulated gene transcription and thus STAT1-mediated control of viral replication. Independently of its catalytic activity, promotes the sorting of chemokine receptor CXCR4 from early endosome to lysosome following CXCL12 stimulation by reducing E3 ligase ITCH activity and thus ITCH-mediated ubiquitination of endosomal sorting complex required for transport ESCRT-0 components HGS and STAM. In addition, required for the recruitment of HGS and STAM to early endosomes. In association with PARP9, plays a role in antiviral responses by mediating 'Lys-48'-linked ubiquitination of encephalomyocarditis virus (EMCV) and human rhinovirus (HRV) C3 proteases and thus promoting their proteosomal-mediated degradation. Belongs to the Deltex family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 11q22
Cellular Component:  cytoplasm; cytosol; early endosome; lysosome; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  enzyme activator activity; enzyme binding; enzyme inhibitor activity; histone binding; STAT family protein binding; ubiquitin-like protein ligase binding; ubiquitin-protein transferase activity
Biological Process:  cellular response to DNA damage stimulus; double-strand break repair; endosome to lysosome transport; histone H2A ubiquitination; histone H2B ubiquitination; histone monoubiquitination; negative regulation of ubiquitin-protein transferase activity; Notch signaling pathway; positive regulation of chromatin binding; positive regulation of defense response to virus by host; positive regulation of double-strand break repair via nonhomologous end joining; positive regulation of NAD+ ADP-ribosyltransferase activity; positive regulation of protein binding; positive regulation of protein localization to early endosome; positive regulation of protein localization to nucleus; positive regulation of receptor catabolic process; positive regulation of transcription, DNA-templated; protein autoubiquitination; protein K48-linked ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  NP_001102523 (RefSeq)
Alt. Names/Synonyms: deltex 3-like; deltex 3-like (Drosophila); deltex E3 ubiquitin ligase 3L; Dtx3l; RGD1565144
Gene Symbols: Dtx3l
Molecular weight: 83,305 Da
Basal Isoelectric point: 8.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene