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eIF2-beta
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of mouse Ortholog: 2 H1|2 76.89 cM |
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Cellular Component:
cytoplasm; eukaryotic translation initiation factor 2 complex; synapse
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Molecular Function:
metal ion binding; mRNA binding; protein binding; translation initiation factor activity; translation initiation factor binding
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Biological Process:
formation of cytoplasmic translation initiation complex; formation of translation preinitiation complex; in utero embryonic development; male germ cell proliferation; male gonad development; translation; translational initiation
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Reference #:
Q99L45
(UniProtKB)
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Alt. Names/Synonyms: 2810026E11Rik; 38kD; 38kDa; AA408636; AA571381; AA986487; AW822225; D2Ertd303; D2Ertd303e; EIF; eIF-2-beta; EIF2; eIF2-beta; EIF2B; Eif2s2; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 (beta); eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa); IF2B; MGC130606; OTTMUSP00000017054
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Gene Symbols: Eif2s2
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Molecular weight:
38,092 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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Translation: eIF2
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Translational Control
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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