eIF2-beta eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 2 H1|2 76.89 cM
Cellular Component:  cytoplasm; eukaryotic translation initiation factor 2 complex
Molecular Function:  metal ion binding; mRNA binding; protein binding; translation initiation factor activity; translation initiation factor binding
Biological Process:  formation of cytoplasmic translation initiation complex; formation of translation preinitiation complex; in utero embryonic development; male germ cell proliferation; male gonad development; translation; translational initiation
Reference #:  Q99L45 (UniProtKB)
Alt. Names/Synonyms: 2810026E11Rik; 38kD; 38kDa; AA408636; AA571381; AA986487; AW822225; D2Ertd303; D2Ertd303e; EIF; eIF-2-beta; EIF2; eIF2-beta; EIF2B; Eif2s2; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 (beta); eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa); IF2B; MGC130606; OTTMUSP00000017054
Gene Symbols: Eif2s2
Molecular weight: 38,092 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  Translation: eIF2  |  Translational Control
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene