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eIF2-beta
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
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Cellular Component:
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Reference #:
P41035
(UniProtKB)
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Alt. Names/Synonyms: eIF-2-beta; eIF2-beta; EIF2S2; Eukaryotic translation initiation factor 2 beta subunit; Eukaryotic translation initiation factor 2 subunit 2; IF2B
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Gene Symbols: EIF2S2
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Molecular weight:
38,326 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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Translation: eIF2
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Translational Control
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