eIF2-beta eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B. Belongs to the eIF-2-beta/eIF-5 family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component:  cytoplasm; cytosol; eukaryotic translation initiation factor 2 complex
Molecular Function:  metal ion binding; protein binding; translation factor activity, RNA binding; translation initiation factor activity
Biological Process:  in utero embryonic development; male germ cell proliferation; male gonad development; translational initiation; transmembrane transport
Reference #:  P20042 (UniProtKB)
Alt. Names/Synonyms: DKFZp686L18198; eIF-2-beta; EIF2; EIF2B; EIF2beta; EIF2S2; eukaryotic initiation factor 2-beta; eukaryotic translation initiation factor 2 beta; Eukaryotic translation initiation factor 2 subunit 2; Eukaryotic translation initiation factor 2 subunit beta; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; IF2B; MGC8508
Gene Symbols: EIF2S2
Molecular weight: 38,388 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling  |  Translation: eIF2  |  Translational Control
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eIF2-beta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene