eIF2B-beta Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Belongs to the eIF-2B alpha/beta/delta subunits family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; GEF; GEF, misc.; RNA-binding; Translation
Chromosomal Location of Human Ortholog: 6q31
Cellular Component:  axon; cytoplasm; eukaryotic translation initiation factor 2B complex
Molecular Function:  ATP binding; GTP binding; guanyl-nucleotide exchange factor activity; translation initiation factor activity
Biological Process:  central nervous system development; hippocampus development; myelination; oligodendrocyte development; ovarian follicle development; positive regulation of axon extension; regulation of translational initiation; response to glucose; response to heat; response to peptide hormone; T cell receptor signaling pathway; translational initiation
Reference #:  Q62818 (UniProtKB)
Alt. Names/Synonyms: EI2BB; eIF-2B GDP-GTP exchange factor subunit beta; Eif2b2; Eif2bb; eukaryotic translation initiation factor 2B, subunit 2 (beta, 39kD); eukaryotic translation initiation factor 2B, subunit 2 beta; Translation initiation factor eIF-2B subunit beta
Gene Symbols: Eif2b2
Molecular weight: 38,875 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
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eIF2B-beta

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene