APOC1 Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. Belongs to the apolipoprotein C1 family. Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Inhibitor; Lipid-binding; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component:  chylomicron; endoplasmic reticulum; extracellular region; high-density lipoprotein particle; very-low-density lipoprotein particle
Molecular Function:  fatty acid binding; lipase inhibitor activity; phosphatidylcholine binding; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipase inhibitor activity
Biological Process:  cholesterol efflux; cholesterol metabolic process; chylomicron remnant clearance; high-density lipoprotein particle remodeling; lipid metabolic process; lipoprotein metabolic process; negative regulation of cholesterol transport; negative regulation of fatty acid biosynthetic process; negative regulation of lipid catabolic process; negative regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; negative regulation of phosphatidylcholine catabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of very-low-density lipoprotein particle clearance; phospholipid efflux; plasma lipoprotein particle remodeling; positive regulation of catalytic activity; positive regulation of cholesterol esterification; regulation of cholesterol transport; triglyceride metabolic process; very-low-density lipoprotein particle assembly; very-low-density lipoprotein particle clearance
Reference #:  P02654 (UniProtKB)
Alt. Names/Synonyms: Apo-CIB; Apo-CIB'; ApoC-IB; ApoC-IB'; APOC1; APOC1B; Apolipoprotein C-I; Apolipoprotein C1; Truncated apolipoprotein C-I
Gene Symbols: APOC1
Molecular weight: 9,332 Da
Basal Isoelectric point: 8.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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