APOC1 Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. Belongs to the apolipoprotein C1 family. Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Inhibitor; Lipid-binding; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7 A3|7 9.94 cM
Cellular Component:  extracellular region; very-low-density lipoprotein particle
Biological Process:  cholesterol metabolic process; lipid transport; lipoprotein metabolic process; triglyceride metabolic process
Reference #:  P34928 (UniProtKB)
Alt. Names/Synonyms: apo-CI; Apo-CIB; Apo-CIB'; apoC-I; ApoC-IB; ApoC-IB'; Apoc1; Apoc1b; Apolipoprotein C-I; Apolipoprotein C1; Truncated apolipoprotein C-I
Gene Symbols: Apoc1
Molecular weight: 9,696 Da
Basal Isoelectric point: 9.05  Predict pI for various phosphorylation states
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APOC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene