PDE5A Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase
Cellular Component: 
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; metal ion binding
Biological Process:  cGMP catabolic process
Reference #:  Q28156 (UniProtKB)
Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; CN5A; PDE5; PDE5A
Gene Symbols: PDE5A
Molecular weight: 98,627 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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PDE5A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein