Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Nucleotide Metabolism - purine; Phosphodiesterase
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; metal ion binding