BRAF Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. Brain and testis. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RAF family; TKL group
Cellular Component: 
Reference #:  P34908 (UniProtKB)
Alt. Names/Synonyms: B-RAF; B-RAF proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase; BRAF; BRAF1; c-RMIL; kinase B-Raf; p94; RAFB1; RMIL; RMIL serine/threonine-protein kinase; Serine/threonine-protein kinase B-raf; v-Raf murine sarcoma viral oncogene homolog B1
Gene Symbols: BRAF
Molecular weight: 89,522 Da
Basal Isoelectric point: 7.84  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene