P130Cas a docking protein containing multiple protein-protein interaction domains. Plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. The amino-terminal SH3 domain regulates its interaction with focal adhesion kinase (FAK) and the FAK-related kinase PYK2 and also with tyrosine phosphatases PTP-1B and PTP-PEST. Overexpression confers antiestrogen resistance on breast cancer cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q12
Cellular Component:  actin cytoskeleton; cytoplasm; focal adhesion; lamellipodium; plasma membrane; ruffle
Molecular Function:  protein binding; protein domain specific binding; protein kinase binding; SH3 domain binding
Biological Process:  actin cytoskeleton organization; actin filament organization; actin filament reorganization; antigen receptor-mediated signaling pathway; B cell receptor signaling pathway; cell adhesion; cell migration; cellular response to endothelin; cellular response to nitric oxide; epidermal growth factor receptor signaling pathway; G-protein coupled receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; insulin receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of substrate adhesion-dependent cell spreading; nerve growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of endothelial cell migration; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q63767 (UniProtKB)
Alt. Names/Synonyms: Bcar1; breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; Cas; CRK-associated substrate; Crkas; p130cas; v-crk-associated tyrosine kinase substrate
Gene Symbols: Bcar1
Molecular weight: 104,262 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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P130Cas

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene