RHOG Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component:  cytosol; endoplasmic reticulum membrane; plasma membrane; secretory granule membrane
Molecular Function:  GTPase activity; protein binding
Biological Process:  actin cytoskeleton organization; activation of GTPase activity; cell chemotaxis; neutrophil degranulation; positive regulation of cell proliferation; positive regulation of protein kinase B signaling; positive regulation of protein localization to plasma membrane; positive regulation of transcription, DNA-templated; Rac protein signal transduction; regulation of ruffle assembly; regulation of small GTPase mediated signal transduction; Rho protein signal transduction
Reference #:  P84095 (UniProtKB)
Alt. Names/Synonyms: ARHG; MGC125835; MGC125836; ras homolog gene family, member G (rho G); Rho-related GTP-binding protein RhoG; RHOG
Gene Symbols: RHOG
Molecular weight: 21,309 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
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RHOG

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene