NMDAR1 Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2 A3|2 17.14 cM
Cellular Component:  cell junction; cell surface; cytoplasm; dendrite; dendrite membrane; dendritic branch; dendritic spine; endoplasmic reticulum; excitatory synapse; glutamatergic synapse; growth cone; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic density membrane; integral component of presynaptic membrane; membrane; neuronal cell body; NMDA selective glutamate receptor complex; parallel fiber to Purkinje cell synapse; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; synapse; synaptic cleft; synaptic membrane; synaptic vesicle; terminal bouton
Molecular Function:  amyloid-beta binding; calcium channel activity; calcium ion binding; calmodulin binding; cation channel activity; enzyme binding; glutamate binding; glutamate receptor binding; glutamate-gated calcium ion channel activity; glycine binding; ion channel activity; ionotropic glutamate receptor activity; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; neurotransmitter binding; NMDA glutamate receptor activity; phosphatase binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein-containing complex binding; signaling receptor activity; signaling receptor binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated cation channel activity
Biological Process:  adult locomotory behavior; associative learning; calcium ion homeostasis; calcium ion transmembrane import into cytosol; calcium ion transport; cation transport; cellular calcium ion homeostasis; cerebral cortex development; chemical synaptic transmission; conditioned taste aversion; excitatory postsynaptic potential; ion transport; ionotropic glutamate receptor signaling pathway; learning; learning or memory; long-term memory; male mating behavior; memory; negative regulation of neuron apoptotic process; neuromuscular process; olfactory learning; pons maturation; positive regulation of apoptotic process; positive regulation of calcium ion transport into cytosol; positive regulation of cell death; positive regulation of cysteine-type endopeptidase activity; positive regulation of dendritic spine maintenance; positive regulation of excitatory postsynaptic potential; positive regulation of reactive oxygen species biosynthetic process; positive regulation of Schwann cell migration; positive regulation of transcription by RNA polymerase II; prepulse inhibition; propylene metabolic process; protein heterotetramerization; protein localization to postsynaptic membrane; protein tetramerization; regulation of axonogenesis; regulation of cell communication; regulation of dendrite morphogenesis; regulation of long-term neuronal synaptic plasticity; regulation of membrane potential; regulation of neuron apoptotic process; regulation of neuronal synaptic plasticity; regulation of respiratory gaseous exchange; regulation of synapse assembly; regulation of synaptic plasticity; respiratory gaseous exchange; response to amphetamine; response to ethanol; response to glycine; response to morphine; rhythmic process; sensory perception of pain; social behavior; startle response; suckling behavior; synaptic transmission, glutamatergic; visual learning
Reference #:  P35438 (UniProtKB)
Alt. Names/Synonyms: GluN1; GluRdelta1; Glurz1; GluRze; GluRzeta1; Glutamate [NMDA] receptor subunit zeta-1; Glutamate receptor ionotropic, NMDA 1; glutamate receptor, ionotropic, NMDA1 (zeta 1); Grin1; M100174; N-methyl-D-aspartate receptor subunit NR1; NMD; NMD-R1; Nmdar; NMDAR1; NMDZ1; NR1; OTTMUSP00000012760; Rgsc1; Rgsc174; RP23-132N23.20
Gene Symbols: Grin1
Molecular weight: 105,481 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene