CREM iso3 Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. Belongs to the bZIP family. Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.alternative promoter
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 18|18 A1
Cellular Component:  cytoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  circadian regulation of gene expression; circadian rhythm; glycosphingolipid metabolic process; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to cAMP; rhythmic process; spermatogenesis
Reference #:  P27699-3 (UniProtKB)
Alt. Names/Synonyms: cAMP responsive element moderator; cAMP responsive element modulator; cAMP-responsive element modulator; Crem; CREM iso3; ICER; ICERI; Inducible cAMP early repressor
Gene Symbols: Crem
Molecular weight: 27,389 Da
Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
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CREM iso3

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene