CREM Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. Belongs to the bZIP family. Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.alternative promoter
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10p11.21
Cellular Component:  cytoplasm; nucleus
Molecular Function:  cAMP response element binding protein binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding
Biological Process:  cell differentiation; fatty acid metabolic process; glucose metabolic process; glycosphingolipid metabolic process; multicellular organism development; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of circadian rhythm; regulation of transcription, DNA-templated; retinoic acid receptor signaling pathway; rhythmic process; signal transduction; spermatogenesis
Reference #:  Q03060 (UniProtKB)
Alt. Names/Synonyms: cAMP response element modulator; cAMP responsive element modulator; cAMP-responsive element modulator; CREM; CREM 2alpha-b protein; CREM 2beta-a protein; CREM-2; hCREM 2alpha-b protein; hCREM 2beta-a protein; hCREM-2; ICER; Inducible cAMP early repressor; inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893
Gene Symbols: CREM
Molecular weight: 37,006 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene