TNNI3K
May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Highly expressed in both adult and fetal heart. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.11.1; HH498 subfamily; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
Chromosomal Location of human Ortholog: 1p31.1 |
Cellular Component:
cytoplasm; nucleus
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
bundle of His cell to Purkinje myocyte communication; protein phosphorylation; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of heart rate
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Disease: Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
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Reference #:
Q59H18
(UniProtKB)
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Alt. Names/Synonyms: Cardiac ankyrin repeat kinase; Cardiac troponin I-interacting kinase; CARK; CCDD; MGC142099; MGC33828; Serine/threonine-protein kinase TNNI3K; TNI3K; TNNI3 interacting kinase; TNNI3-interacting kinase; TNNI3K
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Gene Symbols: TNNI3K
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Molecular weight:
92,851 Da
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Basal Isoelectric point:
6.27
Predict pI for various phosphorylation states
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