TNNI3K May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Highly expressed in both adult and fetal heart. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; HH498 subfamily; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of human Ortholog: 1p31.1
Cellular Component:  cytoplasm; glutamatergic synapse; nucleus
Molecular Function:  ATP binding; metal ion binding; protein binding; protein C-terminus binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; troponin I binding
Biological Process:  bundle of His cell to Purkinje myocyte communication; protein phosphorylation; regulation of cardiac conduction; regulation of cardiac muscle contraction; regulation of heart rate; regulation of postsynapse organization
Disease: Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Reference #:  Q59H18 (UniProtKB)
Alt. Names/Synonyms: Cardiac ankyrin repeat kinase; Cardiac troponin I-interacting kinase; CARK; CCDD; MGC142099; MGC33828; Serine/threonine-protein kinase TNNI3K; TNI3K; TNNI3 interacting kinase; TNNI3-interacting kinase; TNNI3K
Gene Symbols: TNNI3K
Molecular weight: 92,851 Da
Basal Isoelectric point: 6.27  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein