LRRK1 Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; LRRK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 15q26.3
Cellular Component:  cytosol; mitochondrion
Molecular Function:  ATP binding; GTP binding; identical protein binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  bone resorption; negative regulation of peptidyl-tyrosine phosphorylation; osteoclast development; positive regulation of canonical Wnt signaling pathway; positive regulation of intracellular signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation
Reference #:  Q38SD2 (UniProtKB)
Alt. Names/Synonyms: FLJ23119; FLJ27465; KIAA1790; leucine rich repeat kinase 1; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1; RIPK6; Roco1
Gene Symbols: LRRK1
Molecular weight: 225,393 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene