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LRRK1
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; LRRK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of human Ortholog: 15q26.3 |
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Cellular Component:
cytosol; mitochondrion
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Molecular Function:
ATP binding; GTP binding; identical protein binding; metal ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
bone resorption; intracellular signal transduction; negative regulation of peptidyl-tyrosine phosphorylation; osteoclast development; peptidyl-tyrosine phosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of intracellular signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; protein phosphorylation
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Disease: Osteosclerotic Metaphyseal Dysplasia
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Reference #:
Q38SD2
(UniProtKB)
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Alt. Names/Synonyms: FLJ23119; FLJ27465; KIAA1790; leucine rich repeat kinase 1; leucine-rich repeat kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK1; RIPK6; Roco1
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Gene Symbols: LRRK1
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Molecular weight:
225,393 Da
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Basal Isoelectric point:
6.25
Predict pI for various phosphorylation states
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