CAMK2B Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 14q21
Cellular Component:  calcium- and calmodulin-dependent protein kinase complex; cytoplasm; cytosol; dendrite; glutamatergic synapse; microtubule organizing center; neuron projection; organelle; perikaryon; postsynaptic density; sarcoplasmic reticulum membrane; spindle midzone
Molecular Function:  ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; phospholipase binding; protein binding; protein homodimerization activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; structural constituent of postsynaptic actin cytoskeleton
Biological Process:  activation of meiosis involved in egg activation; apoptotic signaling pathway; calcium ion transport; cell differentiation; cell projection morphogenesis; cellular response to homocysteine; G1/S transition of mitotic cell cycle; hippocampal neuron apoptotic process; inhibitory G protein-coupled receptor phosphorylation; long-term synaptic potentiation; nervous system development; neuromuscular process controlling balance; peptidyl-serine phosphorylation; positive regulation of apoptotic signaling pathway; positive regulation of dendritic spine morphogenesis; positive regulation of neuron projection development; positive regulation of phospholipase A2 activity; positive regulation of synapse maturation; postsynaptic actin cytoskeleton organization; protein autophosphorylation; protein phosphorylation; regulation of long-term neuronal synaptic plasticity; regulation of neuron migration; regulation of protein localization to plasma membrane; regulation of synaptic transmission, cholinergic; response to cadmium ion; response to psychosocial stress
Reference #:  P08413 (UniProtKB)
Alt. Names/Synonyms: Ca++/calmodulin-dependent protein kinase II beta subunit; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase type II beta chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; caM-kinase II beta chain; CaMK-II subunit beta; Camk2b; Ck2b; KCC2B
Gene Symbols: Camk2b
Molecular weight: 60,402 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene