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MAP2 iso2
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 9q32 |
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Cellular Component:
actin cytoskeleton; apical dendrite; apical distal dendrite; axon hillock; axon initial segment; basal dendrite; CA3 pyramidal cell dendrite; cell body; cytoplasm; dendrite; dendrite cytoplasm; dendritic branch; dendritic filopodium; dendritic growth cone; dendritic shaft; distal dendrite; glutamatergic synapse; main axon; microtubule; microtubule cytoskeleton; neuron projection; neuronal cell body; nuclear periphery; postsynapse; postsynaptic density; primary dendrite; protein-containing complex; proximal dendrite; proximal neuron projection; ruffle membrane
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Molecular Function:
actin binding; calmodulin binding; dystroglycan binding; microtubule binding; protein binding; protein kinase binding
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Biological Process:
axonogenesis; cellular response to organic substance; central nervous system neuron development; dendrite development; dendrite morphogenesis; establishment of cell polarity; microtubule bundle formation; microtubule cytoskeleton organization; negative regulation of axon extension; negative regulation of microtubule binding; negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization; neuron projection development; positive regulation of anterograde dense core granule transport; positive regulation of anterograde synaptic vesicle transport; regulation of organelle transport along microtubule; regulation of protein localization; response to estradiol; response to progesterone
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Reference #:
P15146-2
(UniProtKB)
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Alt. Names/Synonyms: MAP-2; Map2; MAP2 iso2; MAP2R; Microtubule-associated protein 2; Mtap2
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Gene Symbols: Map2
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Molecular weight:
199,053 Da
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Basal Isoelectric point:
4.73
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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