CDC37 a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 9|9 A3
Cellular Component:  chaperone complex; cytoplasm; cytosol; HSP90-CDC37 chaperone complex; protein-containing complex; ruffle membrane
Molecular Function:  chaperone binding; heat shock protein binding; Hsp90 protein binding; kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; scaffold protein binding; unfolded protein binding
Biological Process:  positive regulation of mitophagy in response to mitochondrial depolarization; posttranscriptional regulation of gene expression; protein folding; protein stabilization; regulation of interferon-gamma-mediated signaling pathway; regulation of protein kinase activity; regulation of type I interferon-mediated signaling pathway
Reference #:  Q61081 (UniProtKB)
Alt. Names/Synonyms: Cdc37; cell division cycle 37 homolog (S. cerevisiae); Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50; p50Cdc37
Gene Symbols: Cdc37
Molecular weight: 44,593 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDC37

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene