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GTF2I iso2
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. Belongs to the TFII-I family. Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 7q11.23 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II-specific DNA-binding transcription factor binding
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Biological Process:
negative regulation of angiogenesis; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II
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Reference #:
P78347-2
(UniProtKB)
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Alt. Names/Synonyms: BAP-135; BAP135; Bruton tyrosine kinase-associated protein 135; BTK-associated protein 135; BTK-associated protein, 135kD; BTKAP1; DIWS; FLJ38776; FLJ56355; General transcription factor II-I; general transcription factor IIi; GTF2I; GTF2I iso2; GTFII-I; IB291; SPIN; SRF-Phox1-interacting protein; TFII-I; WBS; WBSCR6; Williams-Beuren syndrome chromosomal region 6 protein; Williams-Beuren syndrome chromosome region 6
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Gene Symbols: GTF2I
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Molecular weight:
107,970 Da
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Basal Isoelectric point:
8.07
Predict pI for various phosphorylation states
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