carcinoembryonic antigen-related cell adhesion molecule 1 is a cell-cell adhesion molecule that that mediates homophilic cell adhesion in a calcium-independent manner. Has tumor suppressor activity in prostate carcinoma. Plays a role in insulin action and angiogenesis, and is a coinhibitory receptor of T cells, natural killer (NK) and neutrophils. Inhibits TCR-mediated cytotoxicity upon TCR/CD3 complex stimulation by blocking granule exocytosis. Inhibits T cell proliferation and cytokine production. Regulates autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2. Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1. Inhibits IL1B production by upon neutrophils activation. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R. directly associates with annexin II. Regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling. Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production. Belongs to the immunoglobulin superfamily. CEA family. Expressed in columnar epithelial cells of the colon. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, B cells, T cells, NK cells, macrophages, dendritic cells, platelets and neutrophilic granulocytes. Eleven alternatively spliced human isoforms have been described. Eight (isoforms 1, 5-11) are type I membrane proteins, while three (isoforms 2-4) are secreted. The short form (Isoform 7) promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens. The predominant forms expressed by T cells are those containing a long cytoplasmic domain (isoforms 1, 5, 6 and 7). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: adherens junction; apical plasma membrane; basal plasma membrane; brush border membrane; cell junction; cell surface; cell-cell junction; ciliary membrane; external side of plasma membrane; extracellular space; integral component of membrane; integral component of plasma membrane; lateral plasma membrane; membrane; microvillus membrane; plasma membrane; transport vesicle
Molecular Function: actin binding; bile acid transmembrane transporter activity; calmodulin binding; filamin binding; granulocyte colony-stimulating factor receptor binding; identical protein binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase binding; protein phosphatase binding; protein tyrosine kinase binding; Toll-like receptor binding; virion binding; virus receptor activity
Biological Process: bile acid and bile salt transport; blood vessel development; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell junction organization; cellular response to insulin stimulus; common myeloid progenitor cell proliferation; granulocyte colony-stimulating factor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; insulin receptor internalization; negative regulation by host of viral genome replication; negative regulation by host of viral process; negative regulation of bone resorption; negative regulation of cytokine production; negative regulation of cytotoxic T cell degranulation; negative regulation of fatty acid biosynthetic process; negative regulation of granulocyte differentiation; negative regulation of hepatocyte proliferation; negative regulation of interleukin-1 production; negative regulation of interleukin-2 production; negative regulation of JNK cascade; negative regulation of lipid biosynthetic process; negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; negative regulation of protein kinase activity; negative regulation of T cell mediated cytotoxicity; negative regulation of T cell proliferation; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; Peyer's patch development; positive regulation by host of viral process; positive regulation of activation-induced cell death of T cells; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of CD4-positive, alpha-beta T cell activation; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of CD8-positive, alpha-beta T cell activation; positive regulation of homophilic cell adhesion; positive regulation of immunoglobulin secretion; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of T cell proliferation; positive regulation of vasculogenesis; protein homotrimerization; regulation of blood vessel remodeling; regulation of cell growth; regulation of cell migration; regulation of endothelial cell differentiation; regulation of endothelial cell migration; regulation of epidermal growth factor receptor signaling pathway; regulation of ERK1 and ERK2 cascade; regulation of homophilic cell adhesion; regulation of phosphatidylinositol 3-kinase signaling; regulation of sprouting angiogenesis; signal transduction; viral entry into host cell; wound healing, spreading of cells