CTCF a widely expressed, sequence-specific DNA-binding transcriptional regulator, insulator, and organizer of higher-order chromatin structure. Acts as a tumor suppressor. Contains 11 C2H2-type zinc fingers. Involved in promoter activation or repression, hormone-responsive gene silencing, methylation-dependent chromatin insulation, and genomic imprinting. Mediates pairing between X chromosomes and interactions between distant regulatory elements. Binds to promoters of c-myc, PLK, PIM1 and APP. A critical regulator of cell-cycle arrest and death after B cell receptor signaling in immature B cells. CTCF, together with YY1 and Tsix, form a regulated epigenetic switch for X-inactivation. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor; Tumor suppressor
Cellular Component:  nucleus
Molecular Function:  DNA binding; metal ion binding; protein binding
Reference #:  Q08705 (UniProtKB)
Alt. Names/Synonyms: 11-zinc finger protein; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCF; CTCFL paralog; Transcriptional repressor CTCF
Gene Symbols: CTCF
Molecular weight: 82,828 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
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CTCF

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene