TNNI3 Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin I family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of rat Ortholog: 1q12
Cellular Component:  cardiac myofibril; cardiac Troponin complex; contractile fiber; cytoplasm; myofibril; sarcomere; troponin complex
Molecular Function:  actin binding; actin filament binding; calcium channel inhibitor activity; calcium-dependent protein binding; metal ion binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding
Biological Process:  cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle contraction; negative regulation of ATPase activity; regulation of cardiac muscle contraction by calcium ion signaling; regulation of muscle contraction; regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; striated muscle contraction; vasculogenesis; ventricular cardiac muscle tissue morphogenesis
Reference #:  P23693 (UniProtKB)
Alt. Names/Synonyms: Cardiac troponin I; Ctni; Tni; Tnni3; troponin 1, type 3; troponin I type 3 (cardiac); Troponin I, cardiac muscle
Gene Symbols: Tnni3
Molecular weight: 24,160 Da
Basal Isoelectric point: 9.57  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene