SAE2 a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component:  cytoplasm; nucleoplasm; nucleus; SUMO activating enzyme complex
Molecular Function:  ATP binding; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein heterodimerization activity; small protein activating enzyme binding; SUMO activating enzyme activity; SUMO binding; transcription factor binding; transferase activity; ubiquitin-like modifier activating enzyme activity; ubiquitin-like protein conjugating enzyme binding
Biological Process:  protein modification by small protein conjugation; protein sumoylation
Reference #:  Q9Z1F9 (UniProtKB)
Alt. Names/Synonyms: AA986091; Anthracycline-associated resistance ARX; Arx; OTTMUSP00000008744; Sae2; Sumo-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; UBA1; Uba2; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1 (sentrin) activating enzyme subunit 2; Ubiquitin-like 1-activating enzyme E1B; ubiquitin-like modifier activating enzyme 2; Ubl1a2; Uble1b
Gene Symbols: Uba2
Molecular weight: 70,569 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene