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SAE2
a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of Human Ortholog: 7|7 B1 |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus; SUMO activating enzyme complex
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Molecular Function:
ATP binding; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein heterodimerization activity; small protein activating enzyme binding; SUMO activating enzyme activity; SUMO binding; transcription factor binding; transferase activity; ubiquitin-like modifier activating enzyme activity; ubiquitin-like protein conjugating enzyme binding
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Biological Process:
protein modification by small protein conjugation; protein sumoylation
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Reference #:
Q9Z1F9
(UniProtKB)
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Alt. Names/Synonyms: AA986091; Anthracycline-associated resistance ARX; Arx; OTTMUSP00000008744; Sae2; Sumo-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; UBA1; Uba2; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1 (sentrin) activating enzyme subunit 2; Ubiquitin-like 1-activating enzyme E1B; ubiquitin-like modifier activating enzyme 2; Ubl1a2; Uble1b
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Gene Symbols: Uba2
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Molecular weight:
70,569 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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