MOK Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RCK family
Chromosomal Location of mouse Ortholog: 12|12 F1
Cellular Component:  cell projection; ciliary base; cilium; cytoplasm; nucleus
Molecular Function:  ATP binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  intracellular signal transduction; phosphorylation; protein phosphorylation; regulation of gene expression
Reference #:  Q9WVS4 (UniProtKB)
Alt. Names/Synonyms: MAPK/MAK/MRK overlapping kinase; MAPK/MAK/MRK/ overlapping kinase; MGC107277; MGC46883; Mok; MOK protein kinase; Rage; RAGE1; renal tumor antigen; serine/threonine kinase 30; Stk3; Stk30; T/STK 30
Gene Symbols: Mok
Molecular weight: 48,065 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein