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MOK
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; EC 2.7.11.22; Kinase, protein; MOK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RCK family |
| Chromosomal Location of mouse Ortholog: 12|12 F1 |
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Cellular Component:
cell projection; ciliary base; cilium; cytoplasm; nucleus
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Molecular Function:
ATP binding; cyclin-dependent protein serine/threonine kinase activity; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
intracellular signal transduction; phosphorylation; protein phosphorylation
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Reference #:
Q9WVS4
(UniProtKB)
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Alt. Names/Synonyms: MAPK/MAK/MRK overlapping kinase; MAPK/MAK/MRK/ overlapping kinase; MGC107277; MGC46883; Mok; MOK protein kinase; Rage; RAGE1; renal tumor antigen; serine/threonine kinase 30; Stk3; Stk30; T/STK 30
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Gene Symbols: Mok
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Molecular weight:
48,065 Da
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Basal Isoelectric point:
9.54
Predict pI for various phosphorylation states
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