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HIPK4
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; DYRK family; EC 2.7.11.1; HIPK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
ATP binding; histone kinase activity; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
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Biological Process:
chromatin remodeling; histone modification; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein autophosphorylation; regulation of signal transduction by p53 class mediator
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Reference #:
Q8NE63
(UniProtKB)
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Alt. Names/Synonyms: FLJ32818; HIPK4; homeodomain interacting protein kinase 4; Homeodomain-interacting protein kinase 4
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Gene Symbols: HIPK4
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Molecular weight:
69,425 Da
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Basal Isoelectric point:
6.18
Predict pI for various phosphorylation states
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