|
HIPK4
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Note: This description may include information from UniProtKB.
|
| Protein type: CMGC group; DYRK family; EC 2.7.11.1; HIPK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 19q13.2 |
|
Cellular Component:
cytoplasm; nucleus
|
|
Molecular Function:
ATP binding; protein binding; protein serine/threonine kinase activity
|
|
Biological Process:
histone phosphorylation; peptidyl-serine phosphorylation; protein autophosphorylation; regulation of signal transduction by p53 class mediator
|
|
Reference #:
Q8NE63
(UniProtKB)
|
|
Alt. Names/Synonyms: FLJ32818; HIPK4; homeodomain interacting protein kinase 4; Homeodomain-interacting protein kinase 4
|
|
Gene Symbols: HIPK4
|
|
Molecular weight:
69,425 Da
|
|
Basal Isoelectric point:
6.18
Predict pI for various phosphorylation states
|
