HIPK4 Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; EC 2.7.11.1; HIPK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  histone phosphorylation; peptidyl-serine phosphorylation; protein autophosphorylation; regulation of signal transduction by p53 class mediator
Reference #:  Q8NE63 (UniProtKB)
Alt. Names/Synonyms: FLJ32818; HIPK4; homeodomain interacting protein kinase 4; Homeodomain-interacting protein kinase 4
Gene Symbols: HIPK4
Molecular weight: 69,425 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
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HIPK4

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene