TTBK1
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); TTBK family
Cellular Component: cytoplasm; cytosol; microtubule associated complex; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: ATP binding; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process: learning or memory; negative regulation of gene expression; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of astrocyte activation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of cysteine-type endopeptidase activity; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of protein polymerization; protein phosphorylation; signal transduction
