TTBK1 Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); TTBK family
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component:  cytosol; microtubule associated complex; neuronal cell body; nucleoplasm; perinuclear region of cytoplasm
Molecular Function:  ATP binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process:  learning or memory; negative regulation of gene expression; negative regulation of protein binding; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of astrocyte activation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of cysteine-type endopeptidase activity; positive regulation of gene expression; positive regulation of microglial cell activation; positive regulation of protein polymerization; protein phosphorylation
Reference #:  Q5TCY1 (UniProtKB)
Alt. Names/Synonyms: BDTK; Brain-derived tau kinase; KIAA1855; RP3-330M21.4; tau tubulin kinase 1; Tau-tubulin kinase 1; TTBK1
Gene Symbols: TTBK1
Molecular weight: 142,737 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene