TTBK2 Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); TTBK family
Chromosomal Location of mouse Ortholog: 2|2 E5
Cellular Component:  centriole; ciliary basal body; ciliary transition zone; cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus
Molecular Function:  kinesin binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  cerebellar granular layer development; cerebellar granule cell precursor tangential migration; cerebellum development; cilium assembly; embryonic brain development; embryonic digit morphogenesis; forebrain development; microtubule cytoskeleton organization; negative regulation of cellular protein localization; negative regulation of microtubule binding; negative regulation of microtubule depolymerization; negative regulation of protein localization to microtubule; neural tube development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of non-motile cilium assembly; regulation of cell migration; regulation of smoothened signaling pathway; smoothened signaling pathway
Reference #:  Q3UVR3 (UniProtKB)
Alt. Names/Synonyms: 2610507N02Rik; AI326283; B930008N24Rik; Bby; Kiaa0847; mKIAA0847; OTTMUSP00000016715; OTTMUSP00000016716; Protein bartleby; tau tubulin kinase 2; Tau-tubulin kinase 2; Ttbk; Ttbk1; Ttbk2; TTK
Gene Symbols: Ttbk2
Molecular weight: 136,770 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene