SST Somatostatin-14: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Neuronostatin: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH. Belongs to the somatostatin family. Note: This description may include information from UniProtKB.
Protein type: Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 3q27.3
Cellular Component:  extracellular region; extracellular space; GABA-ergic synapse; neuronal cell body; neuronal dense core vesicle
Molecular Function:  hormone activity; protein binding
Biological Process:  cell surface receptor signaling pathway; cell-cell signaling; chemical synaptic transmission; digestion; G protein-coupled receptor signaling pathway; hormone-mediated apoptotic signaling pathway; hyperosmotic response; negative regulation of cell population proliferation; regulation of cell migration; regulation of postsynaptic membrane neurotransmitter receptor levels; response to acidic pH; response to amino acid; response to heat; response to nutrient; response to steroid hormone; response to xenobiotic stimulus
Reference #:  P61278 (UniProtKB)
Alt. Names/Synonyms: Growth hormone release-inhibiting factor; Neuronostatin; NST; prepro-somatostatin; SMS; SMST; Somatostatin; Somatostatin-14; Somatostatin-28; SST; SST-14
Gene Symbols: SST
Molecular weight: 12,736 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene