ZBP1 Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 20q13.31
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  DNA binding; double-stranded RNA adenosine deaminase activity; double-stranded RNA binding; left-handed Z-DNA binding; protein binding; RNA binding
Biological Process:  activation of innate immune response; antiviral innate immune response; apoptotic process; defense response to fungus; defense response to virus; positive regulation of apoptotic process; positive regulation of inflammatory response; positive regulation of necroptotic process; positive regulation of type I interferon-mediated signaling pathway; pyroptosis; regulation of inflammatory response; regulation of interleukin-1-mediated signaling pathway
Reference #:  Q9H171 (UniProtKB)
Alt. Names/Synonyms: C20orf183; DAI; DLM-1; DLM1; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of interferon regulatory factors; DNA-dependent activator of IRFs; Tumor stroma and activated macrophage protein DLM-1; Z-DNA binding protein 1; Z-DNA-binding protein 1; ZBP1
Gene Symbols: ZBP1
Molecular weight: 46,343 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein