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VRK3
Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family |
| Chromosomal Location of human Ortholog: 19q13.33 |
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Cellular Component:
cytoplasm; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus
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Molecular Function:
ATP binding; protein binding; protein phosphatase binding; protein serine/threonine kinase activity
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Biological Process:
negative regulation of ERK1 and ERK2 cascade; peptidyl-serine phosphorylation; positive regulation of phosphoprotein phosphatase activity; signal transduction; skeletal muscle tissue development
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Reference #:
Q8IV63
(UniProtKB)
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Alt. Names/Synonyms: Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; vaccinia related kinase 3; Vaccinia-related kinase 3; VRK serine/threonine kinase 3; VRK3
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Gene Symbols: VRK3
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Molecular weight:
52,881 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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