VRK3 Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CK1 group; EC 2.7.11.1; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); VRK family
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; protein binding; protein phosphatase binding; protein serine/threonine kinase activity
Biological Process:  negative regulation of ERK1 and ERK2 cascade; peptidyl-serine phosphorylation; positive regulation of phosphoprotein phosphatase activity; signal transduction; skeletal muscle tissue development
Reference #:  Q8IV63 (UniProtKB)
Alt. Names/Synonyms: Inactive serine/threonine-protein kinase VRK3; Serine/threonine-protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; vaccinia related kinase 3; Vaccinia-related kinase 3; VRK serine/threonine kinase 3; VRK3
Gene Symbols: VRK3
Molecular weight: 52,881 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VRK3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene