CPA4 Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val. Belongs to the peptidase M14 family. Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.17.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 7q32.2
Cellular Component: 
Molecular Function:  metallocarboxypeptidase activity; zinc ion binding
Biological Process:  histone acetylation
Reference #:  Q9UI42 (UniProtKB)
Alt. Names/Synonyms: Carboxypeptidase A3; Carboxypeptidase A4; CBPA4; CPA3; CPA4
Gene Symbols: CPA4
Molecular weight: 47,351 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
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CPA4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene