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UBF
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nucleolus; Transcription factor |
| Chromosomal Location of rat Ortholog: 10q32.1 |
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Cellular Component:
fibrillar center; nucleolus; nucleus
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Molecular Function:
chromatin binding; DNA binding; protein binding; RNA polymerase I cis-regulatory region sequence-specific DNA binding; RNA polymerase I core promoter sequence-specific DNA binding; RNA polymerase I general transcription initiation factor activity; scaffold protein binding
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Biological Process:
cellular response to leukemia inhibitory factor; positive regulation of transcription by RNA polymerase I; rDNA heterochromatin formation; regulation of glucose mediated signaling pathway; RNA polymerase I preinitiation complex assembly; transcription by RNA polymerase I; transcription elongation by RNA polymerase I; transcription initiation at RNA polymerase I promoter
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Reference #:
P25977
(UniProtKB)
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Alt. Names/Synonyms: Nucleolar transcription factor 1; Tcfubf; transcription factor UBF; UBF; UBF-1; UBF1; Ubtf; upstream binding transcription factor, RNA polymerase I; Upstream-binding factor 1
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Gene Symbols: Ubtf
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Molecular weight:
89,437 Da
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Basal Isoelectric point:
5.63
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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