MARK3 an ubiquitous serine/threonine kinase of the CAMKL family. Phosphorylates Cdc25C on serine 216 and promotes 14-3-3 protein binding. A positive regulator of Wnt signalling. Ubiquitously expressed in human tissues and cell lines. Seven alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12|12 F1
Cellular Component:  cell projection; cytoplasm; dendrite; membrane; plasma membrane
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity; transferase activity
Biological Process:  establishment of cell polarity; intracellular signal transduction; microtubule cytoskeleton organization; negative regulation of hippo signaling; peptidyl-serine autophosphorylation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of protein binding; protein phosphorylation
Reference #:  Q03141 (UniProtKB)
Alt. Names/Synonyms: 1600015G02Rik; A430080F22Rik; ELKL motif kinase 2; EMK-2; Emk2; EMK2/MARK3 serine-threonine protein kinase; ETK-1; ETK1; KIAA4230; MAP/microtubule affinity-regulating kinase 3; Mark3; MPK-10; Mpk10
Gene Symbols: Mark3
Molecular weight: 84,390 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MARK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene