MARK2 a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q43
Cellular Component:  actin filament; basal cortex; cytoplasm; dendrite; lateral plasma membrane; membrane; microtubule bundle; nucleoplasm; nucleus; plasma membrane
Molecular Function:  ATP binding; lipid binding; magnesium ion binding; protein binding; protein N-terminus binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process:  axon development; establishment of cell polarity; establishment or maintenance of cell polarity regulating cell shape; establishment or maintenance of epithelial cell apical/basal polarity; intracellular signal transduction; microtubule cytoskeleton organization; neuron migration; peptidyl-serine phosphorylation; positive regulation of neuron projection development; protein autophosphorylation; protein phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization; regulation of microtubule binding; regulation of microtubule cytoskeleton organization; Wnt signaling pathway
Reference #:  O08679 (UniProtKB)
Alt. Names/Synonyms: ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; Mark2; Serine/threonine-protein kinase MARK2
Gene Symbols: Mark2
Molecular weight: 80,872 Da
Basal Isoelectric point: 9.63  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MARK2

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Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein