GRK2 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Expressed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: AGC group; BARK subfamily; EC; GRK family; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Cellular Component:  cytoplasm; cytosol; membrane; plasma membrane
Molecular Function:  alpha-2A adrenergic receptor binding; ATP binding; beta-adrenergic receptor kinase activity; Edg-2 lysophosphatidic acid receptor binding; G protein-coupled receptor kinase activity; protein binding; protein kinase activity
Biological Process:  cardiac muscle contraction; desensitization of G protein-coupled receptor signaling pathway; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor internalization; G protein-coupled receptor signaling pathway; heart development; intracellular protein transport; negative regulation of striated muscle contraction; negative regulation of the force of heart contraction by chemical signal; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of protein localization to cilium; positive regulation of smoothened signaling pathway; protein phosphorylation; regulation of signal transduction; tachykinin receptor signaling pathway; viral entry into host cell; viral genome replication
Reference #:  P21146 (UniProtKB)
Alt. Names/Synonyms: ADRBK1; ARBK1; BARK; BARK1; Beta-adrenergic receptor kinase 1; Beta-ARK-1; BOS_24950; G protein receptor kinase 2; G- protein coupled receptor kinase 2; GRK2; kinase GRK2
Gene Symbols: ADRBK1
Molecular weight: 79,647 Da
Basal Isoelectric point: 6.88  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
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Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene