| eNOS Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. Belongs to the NOS family. Platelets, placenta, liver and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase |
| Cellular Component: caveola; cytoskeleton; Golgi apparatus |
| Molecular Function: calmodulin binding; heme binding; metal ion binding; NADP binding; nitric-oxide synthase activity |
| Biological Process: arginine catabolic process; blood coagulation; cellular response to laminar fluid shear stress; mitochondrion organization; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of leukocyte cell-cell adhesion; nitric oxide biosynthetic process; positive regulation of guanylate cyclase activity |
| Reference #: P29473 (UniProtKB) |
| Alt. Names/Synonyms: BOS_4740; cNOS; Constitutive NOS; EC-NOS; ECNOS; Endothelial NOS; eNOS; nitric oxide synthase 3 (endothelial cell); Nitric oxide synthase, endothelial; Nitric-oxide synthase, endothelial; NOS, type III; NOS3; NOSIII |
| Gene Symbols: NOS3 |
| Molecular weight: 133,287 Da |
| Basal Isoelectric point: 6.5 Predict pI for various phosphorylation states |
| CST Pathways: AMPK Signaling | Angiogenesis | PI3K/Akt Signaling |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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eNOS |
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| Cross-references to other databases:
AlphaFold
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STRING
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Pfam
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