EphB1 Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Preferentially expressed in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 9|9 F1
Cellular Component:  axon; cell projection; cytoplasm; cytosol; early endosome membrane; endoplasmic reticulum; endosome; filopodium tip; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; neuron projection; plasma membrane; receptor complex
Molecular Function:  ATP binding; axon guidance receptor activity; ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  angiogenesis; axon guidance; camera-type eye morphogenesis; cell adhesion; cell chemotaxis; cell-substrate adhesion; central nervous system projection neuron axonogenesis; cranial nerve development; dendritic spine development; dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; establishment of cell polarity; immunological synapse formation; modulation of chemical synaptic transmission; negative regulation of satellite cell differentiation; negative regulation of skeletal muscle satellite cell proliferation; nervous system development; neural precursor cell proliferation; neurogenesis; optic nerve morphogenesis; phosphorylation; positive regulation of synapse assembly; protein autophosphorylation; protein phosphorylation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of neuron death; retinal ganglion cell axon guidance; skeletal muscle satellite cell activation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q8CBF3 (UniProtKB)
Alt. Names/Synonyms: 9330129L11; AW488255; C130099E04Rik; Cek6; Elk; Elkh; ENSMUSG00000074119; Eph receptor B1; Ephb1; Ephrin type-B receptor 1; Hek6; Net; OTTMUSP00000023194
Gene Symbols: Ephb1
Molecular weight: 109,881 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

EphB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene