EphB1 a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 9|9 F1
Cellular Component:  axon; cell projection; cytoplasm; cytosol; early endosome membrane; endoplasmic reticulum; endosome; filopodium tip; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; neuron projection; plasma membrane; receptor complex
Molecular Function:  ATP binding; axon guidance receptor activity; ephrin receptor activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity
Biological Process:  angiogenesis; axon guidance; camera-type eye morphogenesis; cell adhesion; cell chemotaxis; cell-substrate adhesion; central nervous system projection neuron axonogenesis; cranial nerve development; dendritic spine development; dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; establishment of cell polarity; immunological synapse formation; modulation of chemical synaptic transmission; negative regulation of satellite cell differentiation; negative regulation of skeletal muscle satellite cell proliferation; nervous system development; neural precursor cell proliferation; neurogenesis; optic nerve morphogenesis; phosphorylation; positive regulation of synapse assembly; protein autophosphorylation; protein phosphorylation; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of neuron death; retinal ganglion cell axon guidance; skeletal muscle satellite cell activation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q8CBF3 (UniProtKB)
Alt. Names/Synonyms: 9330129L11; AW488255; C130099E04Rik; Cek6; Elk; Elkh; ENSMUSG00000074119; Eph receptor B1; Ephb1; Ephrin type-B receptor 1; Hek6; Net; OTTMUSP00000023194
Gene Symbols: Ephb1
Molecular weight: 109,881 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

EphB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene