CFTR a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice Note: This description may include information from UniProtKB.
Protein type: Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 4q21
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cell surface; chloride channel complex; cytoplasm; cytoplasmic vesicle membrane; cytosol; dendrite; early endosome; early endosome membrane; endoplasmic reticulum membrane; integral component of membrane; integral component of plasma membrane; membrane; microvillus; neuronal cell body; nucleus; plasma membrane; protein-containing complex; recycling endosome; recycling endosome membrane
Molecular Function:  ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; bicarbonate transmembrane transporter activity; chaperone binding; chloride channel activity; chloride channel inhibitor activity; chloride transmembrane transporter activity; enzyme binding; intracellularly ATP-gated chloride channel activity; isomerase activity; PDZ domain binding; protein binding; Sec61 translocon complex binding
Biological Process:  aging; bicarbonate transport; cellular response to anoxia; cellular response to cAMP; cellular response to forskolin; cellular response to heat; cellular response to hormone stimulus; chloride transmembrane transport; chloride transport; cholesterol biosynthetic process; cholesterol transport; intracellular pH elevation; iodide transport; liver regeneration; lung development; membrane hyperpolarization; multicellular organismal water homeostasis; negative regulation of type B pancreatic cell development; negative regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of blood vessel diameter; positive regulation of cyclic nucleotide-gated ion channel activity; positive regulation of establishment of Sertoli cell barrier; positive regulation of exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of mast cell activation; positive regulation of voltage-gated chloride channel activity; response to cytokine; response to drug; response to endoplasmic reticulum stress; response to estrogen; response to peptide hormone; sperm capacitation; transepithelial chloride transport; transepithelial water transport; transmembrane transport; vasodilation; vesicle docking involved in exocytosis; water transport
Reference #:  P34158 (UniProtKB)
Alt. Names/Synonyms: Abcc7; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; CFTR; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator homolog (human); RGD1561193
Gene Symbols: Cftr
Molecular weight: 167,830 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
Select Structure to View Below

CFTR

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene