CD45 Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 13q13
Cellular Component:  bleb; cell periphery; cell surface; cytoplasmic side of plasma membrane; external side of plasma membrane; focal adhesion; integral component of membrane; integral component of plasma membrane; membrane microdomain; membrane raft; plasma membrane
Molecular Function:  ankyrin binding; heparan sulfate proteoglycan binding; heparin binding; protein binding; protein kinase binding; protein kinase regulator activity; protein tyrosine phosphatase activity; signaling receptor binding; spectrin binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  activation of MAPK activity; B cell differentiation; B cell proliferation; B cell receptor signaling pathway; bone marrow development; calcium-mediated signaling using intracellular calcium source; cell cycle phase transition; cellular response to extracellular stimulus; defense response to virus; dephosphorylation; hematopoietic progenitor cell differentiation; heterotypic cell-cell adhesion; immunoglobulin biosynthetic process; leukocyte cell-cell adhesion; natural killer cell differentiation; negative regulation of cell adhesion involved in substrate-bound cell migration; negative regulation of cytokine-mediated signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 biosynthetic process; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein autophosphorylation; negative regulation of protein kinase activity; negative regulation of protein tyrosine kinase activity; negative regulation of T cell mediated cytotoxicity; negative thymic T cell selection; peptidyl-tyrosine dephosphorylation; plasma membrane raft distribution; positive regulation of alpha-beta T cell proliferation; positive regulation of antigen receptor-mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of gamma-delta T cell differentiation; positive regulation of hematopoietic stem cell migration; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of interleukin-2 biosynthetic process; positive regulation of isotype switching to IgG isotypes; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein tyrosine phosphatase activity; positive regulation of stem cell proliferation; positive regulation of T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell mediated immunity; positive regulation of T cell proliferation; positive regulation of tumor necrosis factor production; positive thymic T cell selection; protein dephosphorylation; regulation of B cell differentiation; regulation of B cell receptor signaling pathway; regulation of cell cycle; regulation of extrinsic apoptotic signaling pathway; regulation of gene expression; regulation of humoral immune response mediated by circulating immunoglobulin; regulation of interleukin-8 production; regulation of JAK-STAT cascade; regulation of phagocytosis; regulation of protein tyrosine kinase activity; release of sequestered calcium ion into cytosol; response to gamma radiation; stem cell development; T cell differentiation; T cell proliferation; T cell receptor signaling pathway
Reference #:  P04157 (UniProtKB)
Alt. Names/Synonyms: CD45; L-CA; Lca; leucocyte common antigen; Leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; protein tyrosine phosphatase, receptor type, C; Protein tyrosine phosphatase, receptor-type, c polypeptide; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein
Gene Symbols: Ptprc
Molecular weight: 143,269 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  T Cell Receptor Signaling
Select Structure to View Below

CD45

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene